Ontology highlight
ABSTRACT:
SUBMITTER: Le Noir S
PROVIDER: S-EPMC5449612 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Le Noir Sandrine S Boyer François F Lecardeur Sandrine S Brousse Mylène M Oruc Zeliha Z Cook-Moreau Jeanne J Denizot Yves Y Cogné Michel M
Nucleic acids research 20170601 10
Cis-regulatory elements feature clustered sites for transcription factors, defining core enhancers and have inter-species homology. The mouse IgH 3΄ regulatory region (3'RR), a major B-cell super-enhancer, consists of four of such core enhancers, scattered throughout more than 25 kb of packaging 'junk DNA', the sequence of which is not conserved but follows a unique palindromic architecture which is conserved in all mammalian species. The 3'RR promotes long-range interactions and potential IgH l ...[more]