Ontology highlight
ABSTRACT:
SUBMITTER: Tao Y
PROVIDER: S-EPMC5449618 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nucleic acids research 20170601 10
HBO1, a member of the MYST family of histone acetyltransferases (HATs), is required for global acetylation of histone H3K14 and embryonic development. It functions as a catalytic subunit in multisubunit complexes comprising a BRPF1/2/3 or JADE1/2/3 scaffold protein, and two accessory proteins. BRPF2 has been shown to be important for the HAT activity of HBO1 toward H3K14. Here we demonstrated that BRPF2 can regulate the HAT activity of HBO1 toward free H3 and H4, and nucleosomal H3. Particularly ...[more]