Ontology highlight
ABSTRACT:
SUBMITTER: Ma M
PROVIDER: S-EPMC5449637 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Ma Miao M Li de la Sierra-Gallay Ines I Lazar Noureddine N Pellegrini Olivier O Durand Dominique D Marchfelder Anita A Condon Ciarán C van Tilbeurgh Herman H
Nucleic acids research 20170601 10
tRNAs are synthesized as precursor RNAs that have to undergo processing steps to become functional. Yeast Trz1 is a key endoribonuclease involved in the 3΄ maturation of tRNAs in all domains of life. It is a member of the β-lactamase family of RNases, characterized by an HxHxDH sequence motif involved in coordination of catalytic Zn-ions. The RNase Z family consists of two subfamilies: the short (250-400 residues) and the long forms (about double in size). Short form RNase Z enzymes act as homod ...[more]