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Crystal structure of a mixed solvated form of amoxapine acetate.

ABSTRACT: The mixed solvated salt 4-(2-chloro-dibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-ium acetate-acetic acid-cyclo-hexane (2/2/1), C17H17ClN3O(+)·C2H3O2 (-)·C2H4O2·0.5C6H12, crystallizes with one mol-ecule of protonated amoxapine (AXPN), an acetate anion and a mol-ecule of acetic acid together with half a mol-ecule of cyclo-hexane. In the centrosymmetric crystal, both enanti-omers of the protonated AXPN mol-ecule stack alternatively along [001]. Acetate anions connect the AXPN cations through N-H?O hydrogen bonding in the [010] direction, creating a sheet lying parallel to (100). The acetic acid mol-ecules are linked to the acetate anions via O-H?O hydrogen bonds within the sheets. Within the sheets there are also a number of C-H?O hydrogen bonds present. The cyclo-hexane solvent mol-ecules occupy the space between the sheets.

SUBMITTER: Bhardwaj RM

PROVIDER: S-EPMC4384552 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Crystal structure of a mixed solvated form of amoxapine acetate.

Bhardwaj Rajni M RM Raval Vishal V Oswald Iain D H ID Florence Alastair J AJ

Acta crystallographica. Section E, Crystallographic communications 20150110 Pt 2

The mixed solvated salt 4-(2-chloro-dibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-ium acetate-acetic acid-cyclo-hexane (2/2/1), C17H17ClN3O(+)·C2H3O2 (-)·C2H4O2·0.5C6H12, crystallizes with one mol-ecule of protonated amoxapine (AXPN), an acetate anion and a mol-ecule of acetic acid together with half a mol-ecule of cyclo-hexane. In the centrosymmetric crystal, both enanti-omers of the protonated AXPN mol-ecule stack alternatively along [001]. Acetate anions connect the AXPN cations through N-H⋯O h ...[more]

PMID: 25878802

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