Ontology highlight
ABSTRACT:
SUBMITTER: Polley S
PROVIDER: S-EPMC5450249 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Polley Soumitra S Seal Soham S Mahapa Avisek A Jana Biswanath B Biswas Anindya A Mandal Sukhendu S Sinha Debabrata D Sau Keya K Sau Subrata S
Bioinformation 20170331 3
Cyclophilins, a class of peptidyl-prolyl cis-trans isomerase (PPIase) enzymes, are inhibited by cyclosporin A (CsA), an immunosuppressive drug. Staphylococcus aureus Newman, a pathogenic bacterium, carries a gene for encoding a putative cyclophilin (SaCyp). SaCyp shows significant homology with other cyclophilins at the sequence level. A three-dimensional model structure of SaCyp harbors a binding site for CsA. To verify whether SaCyp possesses both the PPIase activity and the CsA binding abilit ...[more]