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Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79.


ABSTRACT: Three new indolediterpenoids, namely, 22-hydroxylshearinine F (1), 6-hydroxylpaspalinine (2), and 7-O-acetylemindole SB (3), along with eight related known analogs (4-11), were isolated from the sea-anemone-derived fungus Penicillium sp. AS-79. The structures and relative configurations of these compounds were determined by a detailed interpretation of the spectroscopic data, and their absolute configurations were determined by ECD calculations (1 and 2) and single-crystal X-ray diffraction (3). Some of these compounds exhibited prominent activity against aquatic and human pathogenic microbes.

SUBMITTER: Hu XY 

PROVIDER: S-EPMC5450543 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79.

Hu Xue-Yi XY   Meng Ling-Hong LH   Li Xin X   Yang Sui-Qun SQ   Li Xiao-Ming XM   Wang Bin-Gui BG  

Marine drugs 20170512 5


Three new indolediterpenoids, namely, 22-hydroxylshearinine F (<b>1</b>), 6-hydroxylpaspalinine (<b>2</b>), and 7-<i>O</i>-acetylemindole SB (<b>3</b>), along with eight related known analogs (<b>4</b>-<b>11</b>), were isolated from the sea-anemone-derived fungus <i>Penicillium</i> sp. AS-79. The structures and relative configurations of these compounds were determined by a detailed interpretation of the spectroscopic data, and their absolute configurations were determined by ECD calculations (<  ...[more]

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