Ontology highlight
ABSTRACT:
SUBMITTER: Hashikawa N
PROVIDER: S-EPMC5451194 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Hashikawa Naoya N Utaka Yuta Y Ogawa Takumi T Tanoue Ryo R Morita Yuna Y Yamamoto Sayumi S Yamaguchi Satoru S Kayano Masafumi M Zamami Yoshito Y Hashikawa-Hobara Narumi N
Science advances 20170531 5
Heat shock proteins (HSPs) are stress-induced chaperones that are involved in neurological disease. Although increasingly implicated in behavioral disorders, the mechanisms of HSP action, and the relevant functional pathways, are still unclear. We examined whether oral administration of geranylgeranylacetone (GGA), a known HSP inducer, produced an antidepressant effect in a social defeat stress model of depression in mice. We also investigated the possible molecular mechanisms involved, particul ...[more]