Ontology highlight
ABSTRACT:
SUBMITTER: Seefried L
PROVIDER: S-EPMC5451251 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Seefried Lothar L Baumann Jasmin J Hemsley Sarah S Hofmann Christine C Kunstmann Erdmute E Kiese Beate B Huang Yue Y Chivers Simon S Valentin Marie-Anne MA Borah Babul B Roubenoff Ronenn R Junker Uwe U Jakob Franz F
The Journal of clinical investigation 20170424 6
<h4>Background</h4>Hypophosphatasia (HPP) is a rare genetic disorder resulting in variable alterations of bone formation and mineralization that are caused by mutations in the ALPL gene, encoding the tissue-nonspecific alkaline phosphatase (ALP) enzyme.<h4>Methods</h4>In this phase IIA open-label, single-center, intra-patient, dose-escalating study, adult patients with HPP received 3 ascending intravenous doses of 5, 10, and 20 mg/kg BPS804, a fully human anti-sclerostin monoclonal antibody, on ...[more]