Ontology highlight
ABSTRACT:
SUBMITTER: Tronchere H
PROVIDER: S-EPMC5452048 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Tronchere Helene H Cinato Mathieu M Timotin Andrei A Guitou Laurie L Villedieu Camille C Thibault Helene H Baetz Delphine D Payrastre Bernard B Valet Philippe P Parini Angelo A Kunduzova Oksana O Boal Frederic F
EMBO molecular medicine 20170601 6
PIKfyve is an evolutionarily conserved lipid kinase that regulates pleiotropic cellular functions. Here, we identify PIKfyve as a key regulator of cardiometabolic status and mitochondrial integrity in chronic diet-induced obesity. <i>In vitro</i>, we show that PIKfyve is critical for the control of mitochondrial fragmentation and hypertrophic and apoptotic responses to stress. We also provide evidence that inactivation of PIKfyve by the selective inhibitor STA suppresses excessive mitochondrial ...[more]