Ontology highlight
ABSTRACT:
SUBMITTER: Brace PT
PROVIDER: S-EPMC5453634 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Brace Patience T PT Tezera Liku B LB Bielecka Magdalena K MK Mellows Toby T Garay Diana D Tian Shuye S Rand Lucinda L Green Justin J Jogai Sanjay S Steele Andrew J AJ Millar Timothy M TM Sanchez-Elsner Tilman T Friedland Jon S JS Proud Christopher G CG Elkington Paul T PT
PLoS pathogens 20170601 6
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathways driving inflammatory responses in macrophages have been relatively well described, negative regulatory pathways are less well defined. We hypothesised that Mycobacterium tuberculosis (Mtb) specifically targets negative regulatory pathways to augment immunopathology. Inhibition of signalling through the PI3K/AKT/mTORC1 pathway increased matrix metalloproteinase-1 (MMP-1) gene expression and secr ...[more]