Ontology highlight
ABSTRACT:
SUBMITTER: Andrianne M
PROVIDER: S-EPMC5453703 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Andrianne Mathieu M Assabban Assiya A La Caroline C Mogilenko Denis D Salle Delphine Staumont DS Fleury Sébastien S Doumont Gilles G Van Simaeys Gaëtan G Nedospasov Sergei A SA Blackshear Perry J PJ Dombrowicz David D Goriely Stanislas S Van Maele Laurye L
JCI insight 20170602 11
Tristetraprolin (TTP, encoded by the Zfp36 gene) regulates the mRNA stability of several important cytokines. Due to the critical role of this RNA-binding protein in the control of inflammation, TTP deficiency leads to the spontaneous development of a complex inflammatory syndrome. So far, this phenotype has been largely attributed to dysregulated production of TNF and IL‑23 by myeloid cells, such as macrophages or DCs. Here, we generated mice with conditional deletion of TTP in keratinocytes (Z ...[more]