Intra-articular Recombinant Human Proteoglycan 4 Mitigates Cartilage Damage After Destabilization of the Medial Meniscus in the Yucatan Minipig.

ABSTRACT:

Background

Lubricin, or proteoglycan 4 (PRG4), is a glycoprotein responsible for joint boundary lubrication. PRG4 has been shown previously to be down-regulated after traumatic joint injury such as a meniscal tear. Preliminary evidence suggests that intra-articular injection of PRG4 after injury will reduce cartilage damage in rat models of surgically induced posttraumatic osteoarthritis.

Objective

To determine the efficacy of intra-articular injection of full-length recombinant human lubricin (rhPRG4) for reducing cartilage damage after medial meniscal destabilization (DMM) in a preclinical large animal model.

Study design

Controlled laboratory study.

Methods

Unilateral DMM was performed in 29 Yucatan minipigs. One week after DMM, animals received 3 weekly int

SUBMITTER: Waller KA 

PROVIDER: S-EPMC5453820 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature