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Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis.


ABSTRACT: Visceral leishmaniasis is a neglected disease caused by Leishmania protozoa parasites transmitted by infected sand fly vectors. This disease represents the second in mortality among tropical infections and is associated to a profound immunosuppression state of the host. The hallmark of this infection-induced host immunodeviation is the characteristic high levels of the regulatory interleukin-10 (IL-10) cytokine. In the present study, we investigated the role of B-1 cells in the maintenance of splenic IL-10 levels that could interfere with resistance to parasite infection. Using an experimental murine infection model with Leishmania (L.) infantum chagasi we demonstrated an improved resistance of B-1 deficient BALB/XID mice to infection. BALB/XID mice developed a reduced splenomegaly with diminished splenic parasite burden and lower levels of IL-10 secretion of purified splenocytes at 30 days post-infection, as compared to BALB/c wild-type control mice. Interestingly, we found that resident peritoneal macrophages isolated from BALB/XID mice were more effective to control the parasite load in comparison to cells isolated from BALB/c wild-type mice. Our findings point to a role of B-1 cells in the host susceptibility to visceral leishmaniasis.

SUBMITTER: Arcanjo AF 

PROVIDER: S-EPMC5454060 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis.

Arcanjo Angélica Fernandes AF   Nico Dirlei D   de Castro Gabriellen Menezes Migliani GMM   da Silva Fontes Yasmin Y   Saltarelli Paula P   Decote-Ricardo Debora D   Nunes Marise P MP   Ferreira-Pereira Antônio A   Palatnik-de-Sousa Clarisa B CB   Freire-de-Lima Célio G CG   Morrot Alexandre A  

Frontiers in microbiology 20170602


Visceral leishmaniasis is a neglected disease caused by <i>Leishmania</i> protozoa parasites transmitted by infected sand fly vectors. This disease represents the second in mortality among tropical infections and is associated to a profound immunosuppression state of the host. The hallmark of this infection-induced host immunodeviation is the characteristic high levels of the regulatory interleukin-10 (IL-10) cytokine. In the present study, we investigated the role of B-1 cells in the maintenanc  ...[more]

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