Ontology highlight
ABSTRACT:
SUBMITTER: Lu AT
PROVIDER: S-EPMC5454371 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Lu Ake T AT Hannon Eilis E Levine Morgan E ME Crimmins Eileen M EM Lunnon Katie K Mill Jonathan J Geschwind Daniel H DH Horvath Steve S
Nature communications 20170518
Identifying genes regulating the pace of epigenetic ageing represents a new frontier in genome-wide association studies (GWASs). Here using 1,796 brain samples from 1,163 individuals, we carry out a GWAS of two DNA methylation-based biomarkers of brain age: the epigenetic ageing rate and estimated proportion of neurons. Locus 17q11.2 is significantly associated (P=4.5 × 10<sup>-9</sup>) with the ageing rate across five brain regions and harbours a cis-expression quantitative trait locus for EFCA ...[more]