Ontology highlight
ABSTRACT:
SUBMITTER: Lui NC
PROVIDER: S-EPMC5454373 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Lui Nga Chu NC Tam Wing Yip WY Gao Caiji C Huang Jian-Dong JD Wang Chi Chiu CC Jiang Liwen L Yung Wing Ho WH Kwan Kin Ming KM
Nature communications 20170518
In the cerebellar cortex, Purkinje cells (PCs) receive signals from different inputs through their extensively branched dendrites and serve as an integration centre. Defects in the dendritic development of PCs thus disrupt cerebellar circuitry and cause ataxia. Here we report that specific inactivation of both Lhx1 and Lhx5 in postnatal PCs results in ataxic mutant mice with abnormal dendritic development. The PCs in the mutants have reduced expression of Espin, an F-actin cytoskeleton regulator ...[more]