Ontology highlight
ABSTRACT:
SUBMITTER: de Opakua AI
PROVIDER: S-EPMC5454376 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
de Opakua Alain Ibáñez AI Parag-Sharma Kshitij K DiGiacomo Vincent V Merino Nekane N Leyme Anthony A Marivin Arthur A Villate Maider M Nguyen Lien T LT de la Cruz-Morcillo Miguel Angel MA Blanco-Canosa Juan B JB Ramachandran Sekar S Baillie George S GS Cerione Richard A RA Blanco Francisco J FJ Garcia-Marcos Mikel M
Nature communications 20170518
Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged as critical signalling molecules and therapeutic targets. Here we characterize the molecular mechanism of G-protein activation by a family of non-receptor GEFs containing a Gα-binding and -activating (GBA) motif. We combine NMR spectrosc ...[more]