ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice.
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ABSTRACT:
SUBMITTER: Gusarova V
PROVIDER: S-EPMC5460832 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice.
Gusarova Viktoria V Banfi Serena S Alexa-Braun Corey A CA Shihanian Lisa M LM Mintah Ivory J IJ Lee Joseph S JS Xin Yurong Y Su Qi Q Kamat Vishal V Cohen Jonathan C JC Hobbs Helen H HH Zambrowicz Brian B Yancopoulos George D GD Murphy Andrew J AJ Gromada Jesper J
Endocrinology 20170501 5
Angiopoietin-like protein (ANGPTL)8 is a negative regulator of lipoprotein lipase-mediated plasma triglyceride (TG) clearance. In this study, we describe a fully human monoclonal antibody (REGN3776) that binds monkey and human ANGPTL8 with high affinity. Inhibition of ANGPTL8 with REGN3776 in humanized ANGPTL8 mice decreased plasma TGs and increased lipoprotein lipase activity. Additionally, REGN3776 reduced body weight and fat content. The reduction in body weight was secondary to increased ene ...[more]
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