Ontology highlight
ABSTRACT:
SUBMITTER: Sugden WW
PROVIDER: S-EPMC5455977 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Sugden Wade W WW Meissner Robert R Aegerter-Wilmsen Tinri T Tsaryk Roman R Leonard Elvin V EV Bussmann Jeroen J Hamm Mailin J MJ Herzog Wiebke W Jin Yi Y Jakobsson Lars L Denz Cornelia C Siekmann Arndt F AF
Nature cell biology 20170522 6
The hierarchical organization of properly sized blood vessels ensures the correct distribution of blood to all organs of the body, and is controlled via haemodynamic cues. In current concepts, an endothelium-dependent shear stress set point causes blood vessel enlargement in response to higher flow rates, while lower flow would lead to blood vessel narrowing, thereby establishing homeostasis. We show that during zebrafish embryonic development increases in flow, after an initial expansion of blo ...[more]