Ontology highlight
ABSTRACT:
SUBMITTER: Chen SJ
PROVIDER: S-EPMC5457285 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Chen Shun-Jia SJ Wu Xia X Wadas Brandon B Oh Jang-Hyun JH Varshavsky Alexander A
Science (New York, N.Y.) 20170101 6323
Cells synthesize glucose if deprived of it, and destroy gluconeogenic enzymes upon return to glucose-replete conditions. We found that the Gid4 subunit of the ubiquitin ligase GID in the yeast Saccharomyces cerevisiae targeted the gluconeogenic enzymes Fbp1, Icl1, and Mdh2 for degradation. Gid4 recognized the N-terminal proline (Pro) residue and the ~5-residue-long adjacent sequence motifs. Pck1, the fourth gluconeogenic enzyme, contains Pro at position 2; Gid4 directly or indirectly recognized ...[more]