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[(18)F]-NHC-BF3 adducts as water stable radio-prosthetic groups for PET imaging.

ABSTRACT: The radiofluorination of N-heterocyclic carbene (NHC) boron trifluoride adducts affords novel [(18)F]-positron emission tomography probes which resist hydrolytic fluoride release. The labelling protocol relies on an (18)F-(19)F isotopic exchange reaction promoted by the Lewis acid SnCl4. Modification of the NHC backbone with a maleimide functionality provides access to a model peptide conjugate which shows no evidence of defluorination when imaged in vivo.

SUBMITTER: Chansaenpak K

PROVIDER: S-EPMC5457534 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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[(18)F]-NHC-BF3 adducts as water stable radio-prosthetic groups for PET imaging.

Chansaenpak Kantapat K Wang Mengzhe M Wu Zhanhong Z Zaman Rehmat R Li Zibo Z Gabbaï François P FP

Chemical communications (Cambridge, England) 20150801 62

The radiofluorination of N-heterocyclic carbene (NHC) boron trifluoride adducts affords novel [(18)F]-positron emission tomography probes which resist hydrolytic fluoride release. The labelling protocol relies on an (18)F-(19)F isotopic exchange reaction promoted by the Lewis acid SnCl4. Modification of the NHC backbone with a maleimide functionality provides access to a model peptide conjugate which shows no evidence of defluorination when imaged in vivo. ...[more]

PMID: 26144217

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