Dataset Information

Pathogenicity and transmission of a swine influenza A(H6N6) virus.

ABSTRACT: Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to ?2,6-linked and ?2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.

SUBMITTER: Sun H

PROVIDER: S-EPMC5457681 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Pathogenicity and transmission of a swine influenza A(H6N6) virus.

Sun Hailiang H Kaplan Bryan S BS Guan Minhui M Zhang Guihong G Ye Jianqiang J Long Li-Ping LP Blackmon Sherry S Yang Chun-Kai CK Chiang Meng-Jung MJ Xie Hang H Zhao Nan N Cooley Jim J Smith David F DF Liao Ming M Cardona Carol C Li Lei L Wang George Peng GP Webby Richard R Wan Xiu-Feng XF

Emerging microbes & infections 20170412 4

Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited t ...[more]

PMID: 28400591

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Dataset Information

Pathogenicity and transmission of a swine influenza A(H6N6) virus.

Publications

Pathogenicity and transmission of a swine influenza A(H6N6) virus.

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