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Genetic variations of TLR5 gene interacted with Helicobacter pylori infection among carcinogenesis of gastric cancer.

ABSTRACT: Gastric cancer (GC) ranks the second prevalent cancer type and the second cancer-related death in China. However, the precise mechanisms of GC development remain poorly understood. Chronic infection with Helicobacter pylori is the strongest identified risk factor for GC. Toll-like receptor (TLR) genes, which play critical roles in Helicobacter pylori induced chronic inflammation, may also be implicated in GC susceptibility. TLR5 signaling deficiency could deregulate a cascade of inflammatory events. In current study, we systematically evaluated genetic variations of TLR5, and their interaction with Helicobacter pylori infection among carcinogenesis of gastric cancer, using a large case-controls study among Chinese population. Minor alleles of three SNPS, including rs5744174 (P = 0.001), rs1640827 (P = 0.005), and rs17163737 (P = 0.004), were significantly associated with increased GC risk (OR ranged from 1.20-1.24). Significant interactions with Helicobacter pylori infection were also identified for rs1640827 (P for interaction = 0.009) and rs17163737 (P for interaction = 0.006). These findings suggest that genetic variants in TLR5 may modify the role of Helicobacter pylori infection in the process of causing GC.

SUBMITTER: Xu T 

PROVIDER: S-EPMC5458185 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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[The ratio of Treg/Thl7 cells from mice infected with Plasmodium yoelii in the early stage of infection].

Chen Guang G   Liu Lei L   Bi Sheng S   Luo Lan L   Wang Fang-fang FF   Cai Lian-shun LS   Su Ju-xiang JX   Dai Yue Y  

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20141201 6

<h4>Objective</h4>To investigate the change of Treg/Th17 cell ratio in mice infected with Plasmodium yoelii 17XL in the early stage of infection.<h4>Methods</h4>Forty 6-8 week-old female BALB/c mice were randomly divided into infection group and Treg blockade group. All the mice were infected by intraperitoneal injection with 1 x 10(6) P. yoelii 17XL-parasitized erythrocytes. Mice in Treg blockade group were intraperitoneally injected with 1 mg CD25 mAb before infection and on day 1 post-infecti  ...[more]