Ontology highlight
ABSTRACT:
SUBMITTER: Jeske M
PROVIDER: S-EPMC5458760 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Jeske Mandy M Müller Christoph W CW Ephrussi Anne A
Genes & development 20170523 9
DEAD-box RNA helicases play important roles in a wide range of metabolic processes. Regulatory proteins can stimulate or block the activity of DEAD-box helicases. Here, we show that LOTUS (Limkain, Oskar, and Tudor containing proteins 5 and 7) domains present in the germline proteins Oskar, TDRD5 (Tudor domain-containing 5), and TDRD7 bind and stimulate the germline-specific DEAD-box RNA helicase Vasa. Our crystal structure of the LOTUS domain of Oskar in complex with the C-terminal RecA-like do ...[more]