Ontology highlight
ABSTRACT:
SUBMITTER: Post MR
PROVIDER: S-EPMC5458768 | biostudies-literature | 2017 Mar-Apr
REPOSITORIES: biostudies-literature
Post Michael R MR Tender Gabrielle S GS Lester Henry A HA Dougherty Dennis A DA
eNeuro 20170330 2
A cation-π interaction between the ammonium group of an agonist and a conserved tryptophan termed TrpB is a near universal feature of agonist binding to nicotinic acetylcholine receptors (nAChRs). TrpB is one of five residues that form the aromatic box of the agonist binding site, and for the prototype agonists ACh and nicotine, only TrpB makes a functional cation-π interaction. We report that, in addition to TrpB, a significant cation-π interaction is made to a second aromatic, TyrC2, by the ag ...[more]