Ontology highlight
ABSTRACT:
SUBMITTER: Kohrer S
PROVIDER: S-EPMC5459356 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Köhrer S S Havranek O O Seyfried F F Hurtz C C Coffey G P GP Kim E E Ten Hacken E E Jäger U U Vanura K K O'Brien S S Thomas D A DA Kantarjian H H Ghosh D D Wang Z Z Zhang M M Ma W W Jumaa H H Debatin K-M KM Müschen M M Meyer L H LH Davis R E RE Burger J A JA
Leukemia 20160205 6
Precursor-B-cell receptor (pre-BCR) signaling and spleen tyrosine kinase (SYK) recently were introduced as therapeutic targets for patients with B-cell acute lymphoblastic leukemia (B-ALL), but the importance of this pathway in B-ALL subsets and mechanism of downstream signaling have not fully been elucidated. Here, we provide new detailed insight into the mechanism of pre-BCR signaling in B-ALL. We compared the effects of pharmacological and genetic disruption of pre-BCR signaling in vitro and ...[more]