Ontology highlight
ABSTRACT:
SUBMITTER: Ye W
PROVIDER: S-EPMC5675611 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Ye Wei W Jiang Zhiwu Z Lu Xiaoyun X Ren Xiaomei X Deng Manman M Lin Shouheng S Xiao Yiren Y Lin Simiao S Wang Suna S Li Baiheng B Zheng Yi Y Lai Peilong P Weng Jianyu J Wu Donghai D Ma Yuguo Y Chen Xudong X Wen Zhesheng Z Chen Yaoyu Y Feng Xiaoyan X Li Yangqiu Y Liu Pentao P Du Xin X Pei Duanqing D Yao Yao Y Xu Bing B Ding Ke K Li Peng P
Oncotarget 20160728 50
Available therapeutic options for advanced B cell precursor acute lymphoblastic leukemia (pre-B ALL) are limited. Many lead to neutropenia, leaving patients at risk of life-threatening infections and result in bad outcomes. New treatment options are needed to improve overall survival. We previously showed that GZD824, a novel BCR-ABL tyrosine kinase inhibitor, has anti-tumor activity in Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia cells and tumor models. Here, we show that GZD ...[more]