Ontology highlight
ABSTRACT:
SUBMITTER: Mizuno S
PROVIDER: S-EPMC5459528 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Mizuno Shiro S Farkas Laszlo L Al Husseini Aysar A Farkas Daniela D Gomez-Arroyo Jose J Kraskauskas Donatas D Nicolls Mark R MR Cool Carlyne D CD Bogaard Herman J HJ Voelkel Norbert F NF
American journal of respiratory cell and molecular biology 20120727 5
The combination of chronic hypoxia and treatment of rats with the vascular endothelial growth factor (VEGF) receptor blocker, SU5416, induces pulmonary angio-obliteration, resulting in severe pulmonary arterial hypertension (PAH). Inflammation is thought to contribute to the pathology of PAH. Allergic inflammation caused by ovalbumin (OVA) immunization causes muscularization of pulmonary arteries, but not severe PAH. Whether disturbance of the immune system and allergic inflammation in the setti ...[more]