Ontology highlight
ABSTRACT:
SUBMITTER: Alencar AKN
PROVIDER: S-EPMC6291748 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Alencar Allan K N AKN Pimentel-Coelho Pedro M PM Montes Guilherme C GC da Silva Marina de M C MMC Mendes Luiza V P LVP Montagnoli Tadeu L TL Silva Ananssa M S AMS Vasques Juliana Ferreira JF Rosado-de-Castro Paulo Henrique PH Gutfilen Bianca B Cunha Valéria do M N VDMN Fraga Aline G M AGM Silva Patrícia M R E PMRE Martins Marco Aurélio MA Ferreira Tatiana Paula Teixeira TPT Mendes-Otero Rosalia R Trachez Margarete M MM Sudo Roberto T RT Zapata-Sudo Gisele G
Frontiers in pharmacology 20181206
<b>Aims:</b> Pulmonary arterial hypertension (PAH) is a disease characterized by an increase in pulmonary vascular resistance and right ventricular (RV) failure. We aimed to determine the effects of human mesenchymal stem cell (hMSC) therapy in a SU5416/hypoxia (SuH) mice model of PAH. <b>Methods and Results:</b> C57BL/6 mice (20-25 g) were exposure to 4 weeks of hypoxia combined vascular endothelial growth factor receptor antagonism (20 mg/kg SU5416; weekly <i>s.c.</i> injections; PAH mice). Co ...[more]