The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures.
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ABSTRACT:
SUBMITTER: Mir B
PROVIDER: S-EPMC5459817 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
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The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures.
Mir B B Solés X X González C C Escaja N N
Scientific reports 20170605 1
Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C<sup>+</sup> stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C<sup>+</sup> or psC:psC<sup>+</sup> hemiprotonated base pa ...[more]
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