Engineered clearing agents for the selective depletion of antigen-specific antibodies.
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ABSTRACT:
SUBMITTER: Devanaboyina SC
PROVIDER: S-EPMC5460014 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Engineered clearing agents for the selective depletion of antigen-specific antibodies.
Devanaboyina Siva Charan SC Khare Priyanka P Challa Dilip K DK Ober Raimund J RJ Ward E Sally ES
Nature communications 20170531
Here we have designed a novel class of engineered antibody-based reagents ('Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging. ...[more]
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