Ontology highlight
ABSTRACT:
SUBMITTER: Moffett HF
PROVIDER: S-EPMC6913193 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Moffett Howell F HF Harms Carson K CK Fitzpatrick Kristin S KS Tooley Marti R MR Boonyaratanakornkit Jim J Taylor Justin J JJ
Science immunology 20190501 35
Effective vaccines inducing lifelong protection against many important infections such as respiratory syncytial virus (RSV), HIV, influenza virus, and Epstein-Barr virus (EBV) are not yet available despite decades of research. As an alternative to a protective vaccine, we developed a genetic engineering strategy in which CRISPR-Cas9 was used to replace endogenously encoded antibodies with antibodies targeting RSV, HIV, influenza virus, or EBV in primary human B cells. The engineered antibodies w ...[more]