Ontology highlight
ABSTRACT:
SUBMITTER: Palladino C
PROVIDER: S-EPMC5460287 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Palladino Claudia C Sánchez-Carrillo Marta M Mate-Cano Irene I Vázquez-Morón Sonia S Jimenez-Sousa Ma Ángeles MÁ Gutiérrez-Rivas Mónica M Resino Salvador S Briz Verónica V
Scientific reports 20170606 1
Relevant resistance-associated substitutions (RASs) to elbasvir, the new HCV NS5A inhibitor, may limit its efficacy and lead to virological failure in HCV-GT1a-infected patients. There are few data outside clinical trials evaluating their prevalence and impact of elbasvir/grazoprevir. A multicenter cross-sectional study of 617 HCV-GT1a-infected individuals attended in 84 Spanish hospitals from the 17 Autonomous Communities and two Autonomous cities was performed. HCV population sequencing was us ...[more]