Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a.
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ABSTRACT:
SUBMITTER: Popping S
PROVIDER: S-EPMC7643739 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a.
Popping Stephanie S Verwijs Rosanne R Cuypers Lize L Claassen Mark A MA van den Berk Guido E GE De Weggheleire Anja A Arends Joop E JE Boerekamps Anne A Molenkamp Richard R Koopmans Marion P MP Verbon Annelies A Boucher Charles A B CAB Rijnders Bart J BJ van de Vijver David A M C DAMC
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20201101 8
The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS. ...[more]
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