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Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a.

ABSTRACT: The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.

SUBMITTER: Popping S 

PROVIDER: S-EPMC7643739 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a.

Popping Stephanie S   Verwijs Rosanne R   Cuypers Lize L   Claassen Mark A MA   van den Berk Guido E GE   De Weggheleire Anja A   Arends Joop E JE   Boerekamps Anne A   Molenkamp Richard R   Koopmans Marion P MP   Verbon Annelies A   Boucher Charles A B CAB   Rijnders Bart J BJ   van de Vijver David A M C DAMC  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20201101 8

The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS. ...[more]

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