Ontology highlight
ABSTRACT: Objective
To determine whether the use of inhaled corticosteroids during pregnancy increases the risk of pregnancy induced hypertension and pre-eclampsia among asthmatic women.Design
Nested case-control study.Setting
Three administrative health databases from Quebec: RAMQ, MED-ECHO, and Fichier des evenements demographiques.Participants
3505 women with asthma, totalling 4593 pregnancies, between 1990 and 2000.Main outcome measures
Pregnancy induced hypertension and pre-eclampsia.Results
302 cases of pregnancy induced hypertension and 165 cases of pre-eclampsia were identified. Use of inhaled corticosteroids from conception until date of outcome was not associated with an increased risk of pregnancy induced hypertension (adjusted odds ratio 1.02, 95% confidence interval 0.77 to 1.34) or pre-eclampsia (1.06, 0.74 to 1.53). No significant dose-response relation was observed between inhaled corticosteroids and pregnancy induced hypertension or pre-eclampsia. Oral corticosteroids were significantly associated with the risk of pregnancy induced hypertension (adjusted odds ratio 1.57, 1.02 to 2.41), and a trend was seen for pre-eclampsia (1.72, 0.98 to 3.02).Conclusion
No significant increase of the risk of pregnancy induced hypertension or pre-eclampsia was detected among users of inhaled corticosteroids during pregnancy, while markers of uncontrolled and severe asthma were found to significantly increase the risks of pregnancy induced hypertension and pre-eclampsia.
SUBMITTER: Martel MJ
PROVIDER: S-EPMC546071 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Martel Marie-Josée MJ Rey Evelyne E Beauchesne Marie-France MF Perreault Sylvie S Lefebvre Geneviève G Forget Amélie A Blais Lucie L
BMJ (Clinical research ed.) 20050119 7485
<h4>Objective</h4>To determine whether the use of inhaled corticosteroids during pregnancy increases the risk of pregnancy induced hypertension and pre-eclampsia among asthmatic women.<h4>Design</h4>Nested case-control study.<h4>Setting</h4>Three administrative health databases from Quebec: RAMQ, MED-ECHO, and Fichier des evenements demographiques.<h4>Participants</h4>3505 women with asthma, totalling 4593 pregnancies, between 1990 and 2000.<h4>Main outcome measures</h4>Pregnancy induced hyperte ...[more]