Dataset Information

Zonulin as marker of pregnancy induced hypertension: a case control study.

ABSTRACT: Background:Zonulin has been implicated in many metabolic disorders including hypertension and obesity. However, there is insufficient information about the involvement of zonulin in pregnancy induced hypertension (PIH) which comprises preeclampsia (PE) and gestational hypertension (GH). This study was therefore aimed at finding the level of this biochemical marker of regulation of tight junctions among women with PIH. Methods:A total of 88 women with PIH and 60 age and body mass index (BMI) matched healthy pregnant women controls were enrolled. Blood pressure at 11-13?weeks and after 20?weeks of gestation, body mass index (BMI) in addition to serum Zonulin levels and lipid profile were compared between the groups. Student's t-test was used for comparisons of the mean between the two groups. Correlation analyses were performed using Pearson's correlation and binary logistic regression was used to evaluate the factors associated with PIH. Results:Zonulin level was significantly higher in the participants with PIH as compared to the normal pregnant controls 56.81?±?7.72?ng/ml vs 40.4?±?8.60?ng/ml p?

SUBMITTER: Bawah AT

PROVIDER: S-EPMC7158010 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Zonulin as marker of pregnancy induced hypertension: a case control study.

Bawah Ahmed Tijani AT Tornyi Henry H Seini Mohammed Mustapha MM Ngambire Lincoln Toamsoma LT Yeboah Francis Agyemang FA

Clinical hypertension 20200415

<h4>Background</h4>Zonulin has been implicated in many metabolic disorders including hypertension and obesity. However, there is insufficient information about the involvement of zonulin in pregnancy induced hypertension (PIH) which comprises preeclampsia (PE) and gestational hypertension (GH). This study was therefore aimed at finding the level of this biochemical marker of regulation of tight junctions among women with PIH.<h4>Methods</h4>A total of 88 women with PIH and 60 age and body mass i ...[more]

PMID: 32313692

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Project description:BackgroundGlobally, 292,982 women die due to the complications of pregnancy and childbirth per year, out of those deaths 85% occurs in Sub Saharan Africa. In Ethiopia, pre-eclampsia accounts for 11% of direct maternal deaths.ObjectiveTo determine maternal and foetal outcomes of pregnancy-induced hypertension among women who gave birth at health facilities in Hossana town administration.MethodsInstitutional based unmatched case-control study was conducted among women, who gave birth at health facilities from May 20 to October 30, 2018. By using Epi-Info version 7; 207 sample size was estimated, for each case two controls were selected. Two health facilities were selected using a simple random sampling method. Sample sizes for each facility were allocated proportionally. All cleaned & coded data were entered into Epi-info version 3.5.1 and analysis was carried out using SPSS version 20. Multivariate analysis was performed to determine predictors of pregnancy-induced hypertension at a p-value of <0.05.ResultWomen between 18 to 41 years old had participated in the study with the mean age of 26.00(SD ±4.42), and 25.87(SD ±5.02) for cases and controls respectively. Out of participants 21(30.4%) among cases and 21(15.2%) among controls had developed at least one complication following delivery. 12 (17.4%) and 8 (5.7%) foetal deaths were found in cases and controls groups respectively whereas 15.6% from cases and 3.6% from controls groups women gave birth to the foetus with intra-uterine growth retardation. Women gravidity AOR = 0.32 [95% CI (0.12 0.86)], Previous history of pregnancy-induced hypertension AOR = 22.50 [95% CI (14.95 16.52)] and educational status AOR = 0.32[95% CI (0.12, 0.85)] were identified as predictor of pregnancy-induced hypertension.ConclusionWomen with a previous history of pregnancy-induced hypertension had increased risk of developing pregnancy-induced hypertension, whilst ≥ 3 previous pregnancies and informal educational status decrease odds of developing pregnancy-induced hypertension.

Dataset Information

Zonulin as marker of pregnancy induced hypertension: a case control study.

Publications

Zonulin as marker of pregnancy induced hypertension: a case control study.

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