Ontology highlight
ABSTRACT:
SUBMITTER: Karg T
PROVIDER: S-EPMC5461011 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
The Journal of cell biology 20170512 6
Although poleward segregation of acentric chromosomes is well documented, the underlying mechanisms remain poorly understood. Here, we demonstrate that microtubules play a key role in poleward movement of acentric chromosome fragments generated in <i>Drosophila melanogaster</i> neuroblasts. Acentrics segregate with either telomeres leading or lagging in equal frequency and are preferentially associated with peripheral bundled microtubules. In addition, laser ablation studies demonstrate that seg ...[more]