Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5461494 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Li Yunhui Y Luo Kuntian K Yin Yujiao Y Wu Chenming C Deng Min M Li Lei L Chen Yuping Y Nowsheen Somaira S Lou Zhenkun Z Yuan Jian J
Nature communications 20170601
BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Receptor-associated protein 80 (RAP80) helps recruit BRCA1 to double-strand breaks (DSBs) through the scaffold protein CCDC98 (Abraxas) and facilitates DNA damage response (DDR). However, the regulation of RAP80-BRCA1 complex is still unclear. Here we report that a deubiquitinase, USP13, r ...[more]