Ontology highlight
ABSTRACT:
SUBMITTER: Nho K
PROVIDER: S-EPMC5461522 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nho Kwangsik K Kim Sungeun S Horgusluoglu Emrin E Risacher Shannon L SL Shen Li L Kim Dokyoon D Lee Seunggeun S Foroud Tatiana T Shaw Leslie M LM Trojanowski John Q JQ Aisen Paul S PS Petersen Ronald C RC Jack Clifford R CR Weiner Michael W MW Green Robert C RC Toga Arthur W AW Saykin Andrew J AJ
BMC medical genomics 20170524 Suppl 1
<h4>Background</h4>The APOE ε4 allele is the most significant common genetic risk factor for late-onset Alzheimer's disease (LOAD). The region surrounding APOE on chromosome 19 has also shown consistent association with LOAD. However, no common variants in the region remain significant after adjusting for APOE genotype. We report a rare variant association analysis of genes in the vicinity of APOE with cerebrospinal fluid (CSF) and neuroimaging biomarkers of LOAD.<h4>Methods</h4>Whole genome seq ...[more]