Ontology highlight
ABSTRACT:
SUBMITTER: Agirrezabala X
PROVIDER: S-EPMC5462505 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Agirrezabala Xabier X Samatova Ekaterina E Klimova Mariia M Zamora Miguel M Gil-Carton David D Rodnina Marina V MV Valle Mikel M
Science advances 20170607 6
Bypassing is a recoding event that leads to the translation of two distal open reading frames into a single polypeptide chain. We present the structure of a translating ribosome stalled at the bypassing take-off site of <i>gene 60</i> of bacteriophage T4. The nascent peptide in the exit tunnel anchors the P-site peptidyl-tRNA<sup>Gly</sup> to the ribosome and locks an inactive conformation of the peptidyl transferase center (PTC). The mRNA forms a short dynamic hairpin in the decoding site. The ...[more]