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The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer.

ABSTRACT: Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.

SUBMITTER: Erstad DJ 

PROVIDER: S-EPMC5462520 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer.

Erstad Derek J DJ   Tager Andrew M AM   Hoshida Yujin Y   Fuchs Bryan C BC  

Molecular & cellular oncology 20170331 3

Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC. ...[more]

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