The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer.
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ABSTRACT:
SUBMITTER: Erstad DJ
PROVIDER: S-EPMC5462520 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer.
Erstad Derek J DJ Tager Andrew M AM Hoshida Yujin Y Fuchs Bryan C BC
Molecular & cellular oncology 20170331 3
Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC. ...[more]
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