Ontology highlight
ABSTRACT:
SUBMITTER: Valdes-Rives SA
PROVIDER: S-EPMC5753009 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Valdés-Rives Silvia Anahi SA González-Arenas Aliesha A
Mediators of inflammation 20171221
Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA<sub>1-6</sub>, to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many ca ...[more]