Ontology highlight
ABSTRACT:
SUBMITTER: Lu K
PROVIDER: S-EPMC5464605 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Lu Kevin K Alcivar Allen L AL Ma Jianglin J Foo Tzeh Keong TK Zywea Susan S Mahdi Amar A Huo Yanying Y Kensler Thomas W TW Gatza Michael L ML Xia Bing B
Cancer research 20170417 11
NRF2 is a transcription factor serving as a master regulator of the expression of many genes involved in cellular responses to oxidative and other stresses. In the absence of stress, NRF2 is constantly synthesized but maintained at low levels as it is targeted by KEAP1 for ubiquitination and proteasome-mediated degradation. NRF2 binds KEAP1 mainly through a conserved "ETGE" motif that has also been found in several other proteins, such as DPP3, which has been shown to bind KEAP1 and enhance NRF2 ...[more]