Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC5464849 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Li Linlin L Zhu Lingqun L Hao Bingtao B Gao Wenwen W Wang Qianli Q Li Keyi K Wang Meng M Huang Mengqiu M Liu Zhengjun Z Yang Qiaohong Q Li Xiqing X Zhong Zhuo Z Huang Wenhua W Xiao Guanghui G Xu Yang Y Yao Kaitai K Liu Qiuzhen Q
Oncotarget 20170501 20
Aerobic glycolysis is essential for tumor growth and survival. Activation of multiple carcinogenic signals contributes to metabolism reprogramming during malignant transformation of cancer. Recently nitric oxide has been noted to promote glycolysis but the mechanism remains elusive. We report here the dual role of nitric oxide in glycolysis: low/physiological nitric oxide (≤ 100 nM) promotes glycolysis for ATP production, oxidative defense and cell proliferation of ovary cancer cells, whereas ex ...[more]