Ontology highlight
ABSTRACT:
SUBMITTER: Pan Y
PROVIDER: S-EPMC6787513 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Pan Yanhong Y Wang Wei W Huang Shuai S Ni Wenting W Wei Zhonghong Z Cao Yuzhu Y Yu Suyun S Jia Qi Q Wu Yuanyuan Y Chai Chuan C Zheng Qian Q Zhang Lei L Wang Aiyun A Sun Zhiguang Z Huang Shile S Wang Shijun S Chen Wenxing W Lu Yin Y
Journal of cellular and molecular medicine 20190725 10
Pyruvate kinase M2 (PKM2), playing a central role in regulating aerobic glycolysis, was considered as a promising target for cancer therapy. However, its role in cancer metastasis is rarely known. Here, we found a tight relationship between PKM2 and breast cancer metastasis, demonstrated by the findings that beta-elemene (β-elemene), an approved drug for complementary cancer therapy, exerted distinct anti-metastatic activity dependent on PKM2. The results indicated that β-elemene inhibited breas ...[more]