Ontology highlight
ABSTRACT:
SUBMITTER: Vujic N
PROVIDER: S-EPMC5464855 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Vujic Nemanja N Korbelius Melanie M Leopold Christina C Duta-Mare Madalina M Rainer Silvia S Schlager Stefanie S Goeritzer Madeleine M Kolb Dagmar D Eichmann Thomas O TO Diwoky Clemens C Zimmer Andreas A Zimmermann Robert R Lass Achim A Radovic Branislav B Kratky Dagmar D
Oncotarget 20170501 20
Monoglyceride lipase (MGL) hydrolyzes monoglycerides (MGs) to glycerol and fatty acids. Among various MG species MGL also degrades 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid and potent activator of cannabinoid receptors (CBR) 1 and 2. MGL-knockout (-/-) mice exhibit pronounced 2-AG accumulation, but lack central cannabimimetic effects due to CB1R desensitization. We have previously shown that MGL affects plaque stability in apolipoprotein E (ApoE)-/- mice, an established an ...[more]