Ontology highlight
ABSTRACT:
SUBMITTER: Zandvakili I
PROVIDER: S-EPMC5464989 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zandvakili I I Lin Y Y Morris J C JC Zheng Y Y
Oncogene 20161219 23
Rho GTPases are critical signal transducers of multiple pathways. They have been proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven cancers. Until recently, however, few in vivo studies had been carried out to test this premise. Several recent mouse model studies have verified that Rac1, RhoA, and some of their effector proteins such as PAK and ROCK, are likely anti-cancer targets for treating K-Ras-driven tumours. Other seemingly contradictory studies h ...[more]