Small heat shock proteins in ageing and age-related diseases.
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ABSTRACT:
SUBMITTER: Charmpilas N
PROVIDER: S-EPMC5465026 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Small heat shock proteins in ageing and age-related diseases.
Charmpilas Nikolaos N Kyriakakis Emmanouil E Tavernarakis Nektarios N
Cell stress & chaperones 20170110 4
Small heat shock proteins (sHSPs) are gatekeepers of cellular homeostasis across species, preserving proteome integrity under stressful conditions. Nonetheless, recent evidence suggests that sHSPs are more than molecular chaperones with merely auxiliary role. In contrast, sHSPs have emerged as central lifespan determinants, and their malfunction has been associated with the manifestation of neurological disorders, cardiovascular disease and cancer malignancies. In this review, we focus on the ro ...[more]
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