Ontology highlight
ABSTRACT:
SUBMITTER: Boelens WC
PROVIDER: S-EPMC7332592 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Cell stress & chaperones 20200406 4
Small heat shock proteins function as chaperones by binding unfolding substrate proteins in an ATP-independent manner to keep them in a folding-competent state and to prevent irreversible aggregation. They play crucial roles in diseases that are characterized by protein aggregation, such as neurodegenerative and neuromuscular diseases, but are also involved in cataract, cancer, and congenital disorders. For this reason, these proteins are interesting therapeutic targets for finding molecules tha ...[more]