Ontology highlight
ABSTRACT:
SUBMITTER: Castella B
PROVIDER: S-EPMC5465356 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Castella Barbara B Kopecka Joanna J Sciancalepore Patrizia P Mandili Giorgia G Foglietta Myriam M Mitro Nico N Caruso Donatella D Novelli Francesco F Riganti Chiara C Massaia Massimo M
Nature communications 20170605
Vγ9Vδ2 T cells are activated by phosphoantigens, such as isopentenyl pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting cells. IPP is released in the extracellular microenvironment via unknown mechanisms. Here we show that the ATP-binding cassette transporter A1 (ABCA1) mediates extracellular IPP release from dendritic cells (DC) in cooperation with apolipoprotein A-I (apoA-I) and butyrophilin-3A1. IPP concentrations in the supernatants are sufficient to indu ...[more]