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Monoclonal antibodies in the treatment of multiple sclerosis: emergence of B-cell-targeted therapies.

ABSTRACT: Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS, and one of the most common causes of disability in young adults. Over the last decade, new disease-modifying therapies have emerged, including monoclonal antibodies (mAbs) that provide highly targeted therapies with greater efficacy than platform therapies. In particular, monoclonal antibodies directed against CD20-positive B cells have shown remarkable results in recent clinical trials and renewed interest in the mechanism of B cell-depleting therapies to ameliorate relapse activity and progression in MS. Here, we review the mechanisms of action and clinical evidence of approved and emerging mAbs, with a focus on B cell-targeted therapies.

SUBMITTER: Nguyen AL

PROVIDER: S-EPMC5466523 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Monoclonal antibodies in the treatment of multiple sclerosis: emergence of B-cell-targeted therapies.

Nguyen Ai-Lan AL Gresle Melissa M Marshall Tessa T Butzkueven Helmut H Field Judith J

British journal of pharmacology 20170426 13

Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS, and one of the most common causes of disability in young adults. Over the last decade, new disease-modifying therapies have emerged, including monoclonal antibodies (mAbs) that provide highly targeted therapies with greater efficacy than platform therapies. In particular, monoclonal antibodies directed against CD20-positive B cells have shown remarkable results in recent clinical trials and renewed interest in the mechanism of ...[more]

PMID: 28319650

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